Women with BC referring to infertility centers for fertility preservation are more likely to be deficient in serum 25(OH)D level this subsequently affects the FF 25(OH)D level. In the BC women, the number of dysmorph and highly dysmorph oocytes was higher than in the control group (P < 0.001). There was a significant correlation between the levels of 25(OH)D in FF and serum in BC women (r = 0.873, P 0.05). The mean levels of serum and FF 25(OH)D in BC women were significantly lower than in the control group (22.26 ± 7.98 vs. The serum and follicular fluid (FF) 25(OH)D levels were measured at the time of oocyte retrieval and their relationship to oocyte quality was examined. After initial evaluations, ovarian stimulation began with the GnRH antagonist protocol in the BC group (N = 16) and control group (N = 16). In the present study, the relationship between 25(OH)D levels with oocyte quality in Breast Cancer (BC) women and control group have been investigated. Vitamin D also affects the function of the reproductive system. Recent evidence suggests that vitamin D deficiency could play an important role in the development of non-skeletal diseases, including cancer.
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